GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs60843830 | 1 | rs58461606 | chr2:267367 | SH3YL1 | chr2:218138-264810:- | -0.33 | -4.86 | 4.59E-6 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs6911965 | 1 | rs58479700 | chr6:24483199 | ALDH5A1 | chr6:24495197-24537434:+ | 0.33 | 4.16 | 7.04E-5 | Hematological and biochemical traits |
| THYM | cis | rs6911965 | 1 | rs58479700 | chr6:24483199 | GPLD1 | chr6:24428405-24489850:- | 0.56 | 5.51 | 3.04E-7 | Hematological and biochemical traits |
| THYM | cis | rs9309473 | 1 | rs58603761 | chr2:73726605 | ALMS1P | chr2:73872046-73912692:+ | 0.57 | 4.59 | 1.33E-5 | Metabolite levels |
| THYM | cis | rs2243480 | 1 | rs58669269 | chr7:65951953 | CCT6P1 | chr7:65216092-65228661:+ | 0.6 | 4.86 | 4.72E-6 | Diabetic kidney disease |
| THYM | cis | rs1875620 | 1 | rs59019708 | chr9:91563305 | C9orf47 | chr9:91605778-91611055:+ | -0.26 | -4.68 | 9.7E-6 | Response to statins (LDL cholesterol change) |
| THYM | cis | rs1930961 | 1 | rs59226697 | chr22:25870037 | CRYBB2 | chr22:25615612-25627836:+ | 1.03 | 5.96 | 4.2E-8 | Bipolar disorder with mood-incongruent psychosis |
| THYM | cis | rs9902453 | 1 | rs59274738 | chr17:28437635 | EFCAB5 | chr17:28256874-28435469:+ | 0.31 | 4.23 | 5.4E-5 | Coffee consumption (cups per day) |
| THYM | cis | rs2243480 | 1 | rs59794892 | chr7:65415873 | CCT6P1 | chr7:65216092-65228661:+ | 0.62 | 5.07 | 1.95E-6 | Diabetic kidney disease |
| THYM | cis | rs3820928 | 1 | rs59904960 | chr2:227761269 | RHBDD1 | chr2:227700773-227861591:+ | -0.33 | -4.97 | 3.01E-6 | Pulmonary function |
| THYM | cis | rs8078723 | 1 | rs59925331 | chr17:38169273 | GSDMA | chr17:38119226-38134019:+ | -0.87 | -9.52 | 1.73E-15 | Neutrophil count;White blood cell count;C-reactive protein and white blood cell count |
| THYM | cis | rs60843830 | 1 | rs59937473 | chr2:271797 | SH3YL1 | chr2:218138-264810:- | -0.33 | -4.86 | 4.59E-6 | Spherical equivalent (joint main effects and education interaction) |
| THYM | cis | rs1930961 | 1 | rs5996946 | chr22:25875988 | CRYBB2 | chr22:25615612-25627836:+ | 1.12 | 7.51 | 3.14E-11 | Bipolar disorder with mood-incongruent psychosis |
| THYM | cis | rs7072122 | 1 | rs59980797 | chr10:45049599 | ZNF22 | chr10:45496273-45500776:+ | 0.46 | 4.66 | 1.04E-5 | Estradiol plasma levels (breast cancer) |
| THYM | cis | rs1930961 | 1 | rs6004654 | chr22:25855204 | CRYBB2 | chr22:25615612-25627836:+ | 1.09 | 7.04 | 2.94E-10 | Bipolar disorder with mood-incongruent psychosis |